[HTML][HTML] Requirement of phosphoinositide 3-kinase and Akt for interferon-β-mediated induction of the β-R1 (SCYB11) gene
MRS Rani, L Hibbert, N Sizemore, GR Stark… - Journal of Biological …, 2002 - ASBMB
We previously reported (Rani, MR, Asthagiri, AR, Singh, A., Sizemore, N., Sathe, SS, Li, X.,
DiDonato, JD, Stark, GR, and Ransohoff, RM (2001) J. Biol. Chem. 276, 44365–44368) that
IFN-β induction of β-R1in fibrosarcoma cells required transcription factors ISGF-3 and NF-
κB. IFN-β treatment did not augment the abundance of NF-κB, but led to phosphorylation of
the NF-κB subunit p65 and induced a nuclear activity capable of phosphorylating a p65-GST
fusion construct in the carboxy-terminal transactivation domain (TAD), residues 354–551 …
DiDonato, JD, Stark, GR, and Ransohoff, RM (2001) J. Biol. Chem. 276, 44365–44368) that
IFN-β induction of β-R1in fibrosarcoma cells required transcription factors ISGF-3 and NF-
κB. IFN-β treatment did not augment the abundance of NF-κB, but led to phosphorylation of
the NF-κB subunit p65 and induced a nuclear activity capable of phosphorylating a p65-GST
fusion construct in the carboxy-terminal transactivation domain (TAD), residues 354–551 …
