[HTML][HTML] Interleukin-18 affects local cytokine expression but does not impact on the development of kidney allograft rejection
K Wyburn, H Wu, G Chen, J Yin, J Eris… - American journal of …, 2006 - Elsevier
Interleukin-18 is predominantly a macrophage-derived cytokine with a key role in
inflammation and cell-mediated immunity. Having previously demonstrated IL-18
upregulation in a rat model of kidney rejection, here we examined IL-18 in a fully MHC-
mismatched murine model of acute kidney rejection using IL-18-deficient recipients (IL-
18−/−) and animals administered neutralizing IL-18 binding protein (IL-18BP). Gene
expression of IL-18 and its receptor were significantly upregulated in allografts compared to …
inflammation and cell-mediated immunity. Having previously demonstrated IL-18
upregulation in a rat model of kidney rejection, here we examined IL-18 in a fully MHC-
mismatched murine model of acute kidney rejection using IL-18-deficient recipients (IL-
18−/−) and animals administered neutralizing IL-18 binding protein (IL-18BP). Gene
expression of IL-18 and its receptor were significantly upregulated in allografts compared to …