Toll-like receptor 2 agonists exacerbate accelerated nephrotoxic nephritis
HJ Brown, SH Sacks, MG Robson - Journal of the American …, 2006 - journals.lww.com
Glomerulonephritis can be exacerbated by infection. This study investigated the effect of N-
palmitoyl-S-(2, 3-bis (palmitoyloxy)-(2R, S)-propyl)-(R)-cysteinyl-seryl-(lysyl) 3-lysine (Pam 3
CysSK 4), a synthetic Toll-like receptor 2 (TLR2) ligand, that was given at immunization on
disease severity in accelerated nephrotoxic nephritis. Stimulation of TLR by microbial
constituents is known to influence the development of the adaptive immunity. It was
hypothesized that the TLR2 ligand Pam 3 CysSK 4 can modulate the development of …
palmitoyl-S-(2, 3-bis (palmitoyloxy)-(2R, S)-propyl)-(R)-cysteinyl-seryl-(lysyl) 3-lysine (Pam 3
CysSK 4), a synthetic Toll-like receptor 2 (TLR2) ligand, that was given at immunization on
disease severity in accelerated nephrotoxic nephritis. Stimulation of TLR by microbial
constituents is known to influence the development of the adaptive immunity. It was
hypothesized that the TLR2 ligand Pam 3 CysSK 4 can modulate the development of …