Tumour heterogeneity and metastasis at single-cell resolution
DA Lawson, K Kessenbrock, RT Davis… - Nature cell …, 2018 - nature.com
Nature cell biology, 2018•nature.com
Tumours comprise a heterogeneous collection of cells with distinct genetic and phenotypic
properties that can differentially promote progression, metastasis and drug resistance.
Emerging single-cell technologies provide a new opportunity to profile individual cells within
tumours and investigate what roles they play in these processes. This Review discusses key
technological considerations for single-cell studies in cancer, new findings using single-cell
technologies and critical open questions for future applications.
properties that can differentially promote progression, metastasis and drug resistance.
Emerging single-cell technologies provide a new opportunity to profile individual cells within
tumours and investigate what roles they play in these processes. This Review discusses key
technological considerations for single-cell studies in cancer, new findings using single-cell
technologies and critical open questions for future applications.
Abstract
Tumours comprise a heterogeneous collection of cells with distinct genetic and phenotypic properties that can differentially promote progression, metastasis and drug resistance. Emerging single-cell technologies provide a new opportunity to profile individual cells within tumours and investigate what roles they play in these processes. This Review discusses key technological considerations for single-cell studies in cancer, new findings using single-cell technologies and critical open questions for future applications.
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