[HTML][HTML] Transforming growth factor-β1 regulation of collagenase-3 expression in osteoblastic cells by cross-talk between the Smad and MAPK signaling pathways …
N Selvamurugan, S Kwok, T Alliston, M Reiss… - Journal of Biological …, 2004 - ASBMB
Transforming growth factor-β (TGF-β) plays a key role in osteoblast differentiation and bone
development and remodeling. Collagenase-3 (matrix metalloproteinase-13) is expressed by
osteoblasts and seems to be involved in osteoclastic bone resorption. Here, we show that
TGF-β1 stimulates collagenase-3 expression in the rat osteoblastic cell line UMR 106-01
and requires de novo protein synthesis. Dominant-negative Smad2/3 constructs indicated
that Smad signaling is essential for TGF-β1-stimulated collagenase-3 promoter activity …
development and remodeling. Collagenase-3 (matrix metalloproteinase-13) is expressed by
osteoblasts and seems to be involved in osteoclastic bone resorption. Here, we show that
TGF-β1 stimulates collagenase-3 expression in the rat osteoblastic cell line UMR 106-01
and requires de novo protein synthesis. Dominant-negative Smad2/3 constructs indicated
that Smad signaling is essential for TGF-β1-stimulated collagenase-3 promoter activity …
