PIK3CA mutations in vascular malformations
SD Castillo, E Baselga, M Graupera - Current Opinion in …, 2019 - journals.lww.com
SD Castillo, E Baselga, M Graupera
Current Opinion in Hematology, 2019•journals.lww.comOncogenic mutations on PIK3CA causing lymphatic malformations and venous
malformations are also frequently found in epithelial cancer. Thus, fundamental research
done in the cancer field during the past decades might be applied to the understanding of
lymphatic malformations and venous malformations. Likewise, repurposing PI3K pathway
inhibitors that are currently in cancer clinical trials can be used as a novel strategy for the
treatment of these diseases. Here, we also open a debate for the consideration of lymphatic …
malformations are also frequently found in epithelial cancer. Thus, fundamental research
done in the cancer field during the past decades might be applied to the understanding of
lymphatic malformations and venous malformations. Likewise, repurposing PI3K pathway
inhibitors that are currently in cancer clinical trials can be used as a novel strategy for the
treatment of these diseases. Here, we also open a debate for the consideration of lymphatic …
Summary
Oncogenic mutations on PIK3CA causing lymphatic malformations and venous malformations are also frequently found in epithelial cancer. Thus, fundamental research done in the cancer field during the past decades might be applied to the understanding of lymphatic malformations and venous malformations. Likewise, repurposing PI3K pathway inhibitors that are currently in cancer clinical trials can be used as a novel strategy for the treatment of these diseases. Here, we also open a debate for the consideration of lymphatic malformations and venous malformations as developmental tumours.
Lippincott Williams & Wilkins