Genetic targeting or pharmacologic inhibition of NADPH oxidase nox4 provides renoprotection in long-term diabetic nephropathy
Diabetic nephropathy may occur, in part, as a result of intrarenal oxidative stress. NADPH
oxidases comprise the only known dedicated reactive oxygen species (ROS)–forming
enzyme family. In the rodent kidney, three isoforms of the catalytic subunit of NADPH
oxidase are expressed (Nox1, Nox2, and Nox4). Here we show that Nox4 is the main source
of renal ROS in a mouse model of diabetic nephropathy induced by streptozotocin
administration in ApoE−/− mice. Deletion of Nox4, but not of Nox1, resulted in renal …
oxidases comprise the only known dedicated reactive oxygen species (ROS)–forming
enzyme family. In the rodent kidney, three isoforms of the catalytic subunit of NADPH
oxidase are expressed (Nox1, Nox2, and Nox4). Here we show that Nox4 is the main source
of renal ROS in a mouse model of diabetic nephropathy induced by streptozotocin
administration in ApoE−/− mice. Deletion of Nox4, but not of Nox1, resulted in renal …
