Paclitaxel chemotherapy and vascular toxicity as assessed by flow-mediated and nitrate-mediated vasodilatation
M Vassilakopoulou, G Mountzios, C Papamechael… - Vascular …, 2010 - Elsevier
BACKGROUND: Antitumor activity of paclitaxel is based on promotion of abnormal
microtubule (MT) assembly but it is also considered to have significant pro-inflammatory and
anti-angiogenic effects in vivo and thus may cause vascular dysfunction. METHODS: We
studied 27 women treated with paclitaxel-containing combinations for breast or ovarian
cancer. The control group was represented by 10 women with carcinoma of the uterine
cervix who received low doses of weekly cisplatin as radiation sensitizer. We measured …
microtubule (MT) assembly but it is also considered to have significant pro-inflammatory and
anti-angiogenic effects in vivo and thus may cause vascular dysfunction. METHODS: We
studied 27 women treated with paclitaxel-containing combinations for breast or ovarian
cancer. The control group was represented by 10 women with carcinoma of the uterine
cervix who received low doses of weekly cisplatin as radiation sensitizer. We measured …
