NS-398, a new anti-inflammatory agent, selectively inhibits prostaglandin G/H synthase/cyclooxygenase (COX-2) activity in vitro
N Futaki, S Takahashi, M Yokoyama, I Arai, S Higuchi… - Prostaglandins, 1994 - Elsevier
NS-398 is a novel anti-inflammatory and analgesic agent which produces much fewer
gastrointestinal lesions in rats. Recently, two forms of cyclooxygenase have been identified:
a COX-1 first purified from ram seminal vesicles and a newly discovered mitogen-inducible
form (COX-2). Effects of NS-398 on activities of these two distinct forms of COX were
investigated. COX-1 purified from ram seminal vesicles and COX-2 isolated from sheep
placenta (purity was 70%) were used. The COX-1 activity was completely unaffected by 10 …
gastrointestinal lesions in rats. Recently, two forms of cyclooxygenase have been identified:
a COX-1 first purified from ram seminal vesicles and a newly discovered mitogen-inducible
form (COX-2). Effects of NS-398 on activities of these two distinct forms of COX were
investigated. COX-1 purified from ram seminal vesicles and COX-2 isolated from sheep
placenta (purity was 70%) were used. The COX-1 activity was completely unaffected by 10 …
