[HTML][HTML] Airway surface dehydration by transforming growth factor β (TGF-β) in cystic fibrosis is due to decreased function of a voltage-dependent potassium channel …
D Manzanares, S Krick, N Baumlin, JS Dennis… - Journal of Biological …, 2015 - ASBMB
Transforming growth factor β1 (TGF-β1) is not only elevated in airways of cystic fibrosis (CF)
patients, whose airways are characterized by abnormal ion transport and mucociliary
clearance, but TGF-β1 is also associated with worse clinical outcomes. Effective mucociliary
clearance depends on adequate airway hydration, governed by ion transport. Apically
expressed, large-conductance, Ca 2+-and voltage-dependent K+(BK) channels play an
important role in this process. In this study, TGF-β1 decreased airway surface liquid volume …
patients, whose airways are characterized by abnormal ion transport and mucociliary
clearance, but TGF-β1 is also associated with worse clinical outcomes. Effective mucociliary
clearance depends on adequate airway hydration, governed by ion transport. Apically
expressed, large-conductance, Ca 2+-and voltage-dependent K+(BK) channels play an
important role in this process. In this study, TGF-β1 decreased airway surface liquid volume …
