[HTML][HTML] Functional apical large conductance, Ca2+-activated, and voltage-dependent K+ channels are required for maintenance of airway surface liquid volume
D Manzanares, C Gonzalez, P Ivonnet, RS Chen… - Journal of Biological …, 2011 - ASBMB
Large conductance, Ca 2+-activated, and voltage-dependent K+(BK) channels control a
variety of physiological processes in nervous, muscular, and renal epithelial tissues. In
bronchial airway epithelia, extracellular ATP-mediated, apical increases in intracellular Ca
2+ are important signals for ion movement through the apical membrane and regulation of
water secretion. Although other, mainly basolaterally expressed K+ channels are recognized
as modulators of ion transport in airway epithelial cells, the role of BK in this process …
variety of physiological processes in nervous, muscular, and renal epithelial tissues. In
bronchial airway epithelia, extracellular ATP-mediated, apical increases in intracellular Ca
2+ are important signals for ion movement through the apical membrane and regulation of
water secretion. Although other, mainly basolaterally expressed K+ channels are recognized
as modulators of ion transport in airway epithelial cells, the role of BK in this process …