Efficacy and safety of LY315920Na/S-5920, a selective inhibitor of 14-kDa group IIA secretory phospholipase A2, in patients with suspected sepsis and organ failure
E Abraham, C Naum, V Bandi, D Gervich… - Critical care …, 2003 - journals.lww.com
Objective Concentrations of group IIA secretory phospholipase A 2, an inflammatory
response mediator, are increased in the plasma of patients with sepsis and septic shock,
and the extent of elevation is correlated with mortality. LY315920Na/S-5920 is a selective
inhibitor of group IIA secretory phospholipase A 2 that has been shown to inhibit serum
group IIA secretory phospholipase A 2 enzyme activity in patients with severe sepsis. The
primary objectives of this study were to determine whether there was a dose-response …
response mediator, are increased in the plasma of patients with sepsis and septic shock,
and the extent of elevation is correlated with mortality. LY315920Na/S-5920 is a selective
inhibitor of group IIA secretory phospholipase A 2 that has been shown to inhibit serum
group IIA secretory phospholipase A 2 enzyme activity in patients with severe sepsis. The
primary objectives of this study were to determine whether there was a dose-response …