A predictive model for the clearance of soluble phospholipase A2 during septic shock
P Vadas, W Pruzanski… - The Journal of laboratory …, 1991 - translationalres.com
Abstract Circulating phospholipase A 2 (PLA 2) has been recognized as a mediator of
cardiovascular collapse in septic shock. Proximal mediators of endotoxemia, including tumor
necrosis factor and interleukin 1, induce PLA 2 synthesis and release, but the factors
regulating PLA 2 elimination are unknown. Similarly, the kinetics of PLA 2 clearance during
recovery from septic shock have not been examined. An autoregressive mathematical model
was developed to describe the rate of PLA 2 clearance during the recovery phase of septic …
cardiovascular collapse in septic shock. Proximal mediators of endotoxemia, including tumor
necrosis factor and interleukin 1, induce PLA 2 synthesis and release, but the factors
regulating PLA 2 elimination are unknown. Similarly, the kinetics of PLA 2 clearance during
recovery from septic shock have not been examined. An autoregressive mathematical model
was developed to describe the rate of PLA 2 clearance during the recovery phase of septic …