Specific recognition of cruciform DNA by nuclear protein HMG1
ME Bianchi, M Beltrame, G Paonessa - Science, 1989 - science.org
ME Bianchi, M Beltrame, G Paonessa
Science, 1989•science.orgCruciform DNA, a non-double helix form of DNA, can be generated as an intermediate in
genetic recombination as well as from palindromic sequences under the effect of
supercoiling. Eukaryotic cells are equipped with a DNA-binding protein that selectively
recognizes cruciform DNA. Biochemical and immunological data showed that this protein is
HMG1, an evolutionarily conserved, essential, and abundant component of the nucleus. The
interaction with a ubiquitous protein points to a critical role for cruciform DNA conformations.
genetic recombination as well as from palindromic sequences under the effect of
supercoiling. Eukaryotic cells are equipped with a DNA-binding protein that selectively
recognizes cruciform DNA. Biochemical and immunological data showed that this protein is
HMG1, an evolutionarily conserved, essential, and abundant component of the nucleus. The
interaction with a ubiquitous protein points to a critical role for cruciform DNA conformations.
Cruciform DNA, a non-double helix form of DNA, can be generated as an intermediate in genetic recombination as well as from palindromic sequences under the effect of supercoiling. Eukaryotic cells are equipped with a DNA-binding protein that selectively recognizes cruciform DNA. Biochemical and immunological data showed that this protein is HMG1, an evolutionarily conserved, essential, and abundant component of the nucleus. The interaction with a ubiquitous protein points to a critical role for cruciform DNA conformations.
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