Pathology and genetics of hereditary colorectal cancer
H Ma, LAA Brosens, GJA Offerhaus, FM Giardiello… - Pathology, 2018 - Elsevier
Colorectal cancer (CRC) accounts for over 8% of all deaths annually worldwide. Between 2
and 5% of all CRCs occur due to inherited syndromes, including Lynch syndrome, familial
adenomatous polyposis, MUTYH-associated polyposis, Peutz–Jeghers syndrome, juvenile
polyposis and Cowden/PTEN hamartoma syndrome. In addition, serrated polyposis is a
clinically defined condition characterised by multiple colorectal serrated polyps and an
increased risk of CRC but the genetics are not known. In most hereditary CRC syndromes …
and 5% of all CRCs occur due to inherited syndromes, including Lynch syndrome, familial
adenomatous polyposis, MUTYH-associated polyposis, Peutz–Jeghers syndrome, juvenile
polyposis and Cowden/PTEN hamartoma syndrome. In addition, serrated polyposis is a
clinically defined condition characterised by multiple colorectal serrated polyps and an
increased risk of CRC but the genetics are not known. In most hereditary CRC syndromes …