[HTML][HTML] Combined liver X receptor/peroxisome proliferator-activated receptor γ agonist treatment reduces amyloid β levels and improves behavior in amyloid …
R Skerrett, MP Pellegrino, BT Casali… - Journal of Biological …, 2015 - ASBMB
Alzheimer disease (AD) is characterized by the extracellular accumulation of amyloid β (Aβ),
which is accompanied by a robust inflammatory response in the brain. Both of these
pathogenic processes are regulated by nuclear receptors, including the liver X receptors
(LXRs) and peroxisome-proliferator receptor γ (PPARγ). Agonists of LXRs have been
demonstrated previously to reduce Aβ levels and improve cognitive deficits in AD mouse
models by inducing the transcription and lipidation of apolipoprotein E (apoE). Agonists …
which is accompanied by a robust inflammatory response in the brain. Both of these
pathogenic processes are regulated by nuclear receptors, including the liver X receptors
(LXRs) and peroxisome-proliferator receptor γ (PPARγ). Agonists of LXRs have been
demonstrated previously to reduce Aβ levels and improve cognitive deficits in AD mouse
models by inducing the transcription and lipidation of apolipoprotein E (apoE). Agonists …