[HTML][HTML] Astrocytes secrete exosomes enriched with proapoptotic ceramide and prostate apoptosis response 4 (PAR-4): potential mechanism of apoptosis induction in …
G Wang, M Dinkins, Q He, G Zhu, C Poirier… - Journal of Biological …, 2012 - ASBMB
Amyloid protein is well known to induce neuronal cell death, whereas only little is known
about its effect on astrocytes. We found that amyloid peptides activated caspase 3 and
induced apoptosis in primary cultured astrocytes, which was prevented by caspase 3
inhibition. Apoptosis was also prevented by shRNA-mediated down-regulation of PAR-4, a
protein sensitizing cells to the sphingolipid ceramide. Consistent with a potentially
proapoptotic effect of PAR-4 and ceramide, astrocytes surrounding amyloid plaques in brain …
about its effect on astrocytes. We found that amyloid peptides activated caspase 3 and
induced apoptosis in primary cultured astrocytes, which was prevented by caspase 3
inhibition. Apoptosis was also prevented by shRNA-mediated down-regulation of PAR-4, a
protein sensitizing cells to the sphingolipid ceramide. Consistent with a potentially
proapoptotic effect of PAR-4 and ceramide, astrocytes surrounding amyloid plaques in brain …