[HTML][HTML] Functional characterization of JMJD2A, a histone deacetylase-and retinoblastoma-binding protein
To effectively direct targeted repression, the class I histone deacetylases (HDACs) associate
with many important regulatory proteins. In this paper we describe the molecular
characterization of a member of the Jumonji domain 2 (JMJD2) family of proteins, and
demonstrate its binding to both class I HDACs and the retinoblastoma protein (pRb). JMJD2
proteins are characterized by the presence of two leukemia-associated protein/plant
homeodomain (LAP/PHD) zinc fingers, one JmjN, one JmjC (containing an internal …
with many important regulatory proteins. In this paper we describe the molecular
characterization of a member of the Jumonji domain 2 (JMJD2) family of proteins, and
demonstrate its binding to both class I HDACs and the retinoblastoma protein (pRb). JMJD2
proteins are characterized by the presence of two leukemia-associated protein/plant
homeodomain (LAP/PHD) zinc fingers, one JmjN, one JmjC (containing an internal …