The ratio of ADP-to ATP-ectonucleotidase activity is reduced in patients with coronary artery disease
MM El-Omar, N Islam, MJ Broekman… - Thrombosis research, 2005 - Elsevier
INTRODUCTION: CD39 (NTPDase1), an endothelial cell membrane glycoprotein, is the
predominant ATP diphosphohydrolase (ATPDase) in vascular endothelium. It hydrolyses
both triphosphonucleosides and diphosphonucleosides at comparable rates, thus
terminating platelet aggregation and recruitment responses to ADP and other platelet
agonists. This occurs even when nitric oxide (NO) formation and prostacyclin production are
inhibited. Thus, CD39 represents the main control system for platelet reactivity. Reduced or …
predominant ATP diphosphohydrolase (ATPDase) in vascular endothelium. It hydrolyses
both triphosphonucleosides and diphosphonucleosides at comparable rates, thus
terminating platelet aggregation and recruitment responses to ADP and other platelet
agonists. This occurs even when nitric oxide (NO) formation and prostacyclin production are
inhibited. Thus, CD39 represents the main control system for platelet reactivity. Reduced or …