Gap junction development is correlated with insulin content in the pancreatic B cell
P Meda, P Halban, A Perrelet, AE Renold, L Orci - Science, 1980 - science.org
P Meda, P Halban, A Perrelet, AE Renold, L Orci
Science, 1980•science.orgThe development of gap junctions between insulin-containing B cells was quantitatively
analyzed in islets of Langerhans isolated from rats treated with the sulfonylurea
glibenclamid for 1, 2, or 7 days. Glibenclamid treatment was associated with a marked
depletion of the insulin content of B cells and with an increase in the number and size of gap
junctions between these cells. A significant correlation was found between these two events.
analyzed in islets of Langerhans isolated from rats treated with the sulfonylurea
glibenclamid for 1, 2, or 7 days. Glibenclamid treatment was associated with a marked
depletion of the insulin content of B cells and with an increase in the number and size of gap
junctions between these cells. A significant correlation was found between these two events.
The development of gap junctions between insulin-containing B cells was quantitatively analyzed in islets of Langerhans isolated from rats treated with the sulfonylurea glibenclamid for 1, 2, or 7 days. Glibenclamid treatment was associated with a marked depletion of the insulin content of B cells and with an increase in the number and size of gap junctions between these cells. A significant correlation was found between these two events.
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