TGT3, Thyroid Transcription Factor I, and Sp1 Elements Regulate Transcriptional Activity of the 1.3-Kilobase Pair Promoter ofT1α, a Lung Alveolar Type I Cell Gene
MI Ramirez, AK Rishi, YX Cao, MC Williams - Journal of Biological …, 1997 - ASBMB
Alveolar type I epithelial cells form the major surface for gas exchange in the lung. To
explore how type I cells differ in gene expression from their progenitor alveolar type II cells,
we analyzed transcriptional regulation of T1α, a gene expressed by adult type I but not type
II cells. In vivodevelopmental patterns of T1α expression in lung and brain suggest active
gene regulation. We cloned and sequenced 1.25 kilobase pairs of the T1α promoter that can
drive reporter expression in lung epithelial cell lines. Deletion analyses identified regions …
explore how type I cells differ in gene expression from their progenitor alveolar type II cells,
we analyzed transcriptional regulation of T1α, a gene expressed by adult type I but not type
II cells. In vivodevelopmental patterns of T1α expression in lung and brain suggest active
gene regulation. We cloned and sequenced 1.25 kilobase pairs of the T1α promoter that can
drive reporter expression in lung epithelial cell lines. Deletion analyses identified regions …
