Efficacy of topical application of eosin for ulcerated hemangiomas
M Lapidoth, D Ben-Amitai, S Bhandarkar, L Fried… - Journal of the American …, 2009 - jaad.org
To the Editor: Ulceration is the most common complication of infantile hemangiomas. 1
Recent studies suggest that ulceration may arise because of an imbalance between
angiopoietin-2 (Ang-2) and vascular endothelial growth factor (VEGF), because Ang-2
promotes angiogenesis in the presence of VEGF but causes endothelial cell death in the
absence of VEGF. 2 Agents that decrease the production of Ang-2 might promote ulcer
healing. Recently, we showed that triphenylmethane dyes including gentian violet and …
Recent studies suggest that ulceration may arise because of an imbalance between
angiopoietin-2 (Ang-2) and vascular endothelial growth factor (VEGF), because Ang-2
promotes angiogenesis in the presence of VEGF but causes endothelial cell death in the
absence of VEGF. 2 Agents that decrease the production of Ang-2 might promote ulcer
healing. Recently, we showed that triphenylmethane dyes including gentian violet and …