[HTML][HTML] Biosynthesis of the Phagocyte NADPH Oxidase Cytochromeb 558: ROLE OF HEME INCORPORATION AND HETERODIMER FORMATION IN MATURATION …
L Yu, L Zhen, MC Dinauer - Journal of Biological Chemistry, 1997 - ASBMB
The NADPH oxidase cytochromeb 558 is a membrane heterodimer comprised of a
glycosylated 91-kDa subunit, gp91 phox, and a nonglycosylated 22-kDa subunit, p22 phox.
The role of heme in cytochrome b 558 biosynthesis was studied using succinyl acetone, an
inhibitor of heme synthesis, in PLB-985 myeloid cells undergoing granulocytic
differentiation. Succinyl acetone markedly reduced expression of p22 phox and the mature
91-kDa form of gp91 phox but not its 65-kDa high mannose precursor, in association with a …
glycosylated 91-kDa subunit, gp91 phox, and a nonglycosylated 22-kDa subunit, p22 phox.
The role of heme in cytochrome b 558 biosynthesis was studied using succinyl acetone, an
inhibitor of heme synthesis, in PLB-985 myeloid cells undergoing granulocytic
differentiation. Succinyl acetone markedly reduced expression of p22 phox and the mature
91-kDa form of gp91 phox but not its 65-kDa high mannose precursor, in association with a …