Protein kinase C family functions in B-cell activation
B Guo, TT Su, DJ Rawlings - Current opinion in immunology, 2004 - Elsevier
B Guo, TT Su, DJ Rawlings
Current opinion in immunology, 2004•ElsevierMembers of the protein kinase C (PKC) family play important but distinct roles in B-cell
activation, as demonstrated by emerging genetic and biochemical studies. PKCβ is
indispensable for B-cell antigen receptor (BCR)-induced NF-κB activation and B-cell
survival. Recent evidence indicates that PKCβ might regulate inhibitor of κB kinase (IKK)
and NF-κB activation through interaction with the CARMA1/Bcl10/MALT signaling complex
in BCR microdomains. By contrast, the novel PKC isoform PKCδ is specifically required to …
activation, as demonstrated by emerging genetic and biochemical studies. PKCβ is
indispensable for B-cell antigen receptor (BCR)-induced NF-κB activation and B-cell
survival. Recent evidence indicates that PKCβ might regulate inhibitor of κB kinase (IKK)
and NF-κB activation through interaction with the CARMA1/Bcl10/MALT signaling complex
in BCR microdomains. By contrast, the novel PKC isoform PKCδ is specifically required to …
Members of the protein kinase C (PKC) family play important but distinct roles in B-cell activation, as demonstrated by emerging genetic and biochemical studies. PKCβ is indispensable for B-cell antigen receptor (BCR)-induced NF-κB activation and B-cell survival. Recent evidence indicates that PKCβ might regulate inhibitor of κB kinase (IKK) and NF-κB activation through interaction with the CARMA1/Bcl10/MALT signaling complex in BCR microdomains. By contrast, the novel PKC isoform PKCδ is specifically required to maintain the tolerance of self-reactive B cells.
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