Lipocalin 24p3 is regulated by the Wnt pathway independent of regulation by iron
S Ziegler, S Röhrs, L Tickenbrock, A Langerak… - Cancer genetics and …, 2007 - Elsevier
Lipocalin 24p3 plays a direct role in iron transport and regulates the levels of important
proteins of the iron metabolism. Iron-loaded 24p3 binds to its specific receptor (24p3R) on
the cell surface. Upon binding to its receptor, 24p3 is internalized into the cell, where it
releases its bound iron. Iron-free 24p3 can withdraw iron from inside the cell to the outside
by a reverse mechanism. We analyzed the role of the murine 24p3 gene Lcn2 (alias 24p3)
as a target of the Wnt pathway. In cells with activated Wnt pathway, the levels of 24p3 protein …
proteins of the iron metabolism. Iron-loaded 24p3 binds to its specific receptor (24p3R) on
the cell surface. Upon binding to its receptor, 24p3 is internalized into the cell, where it
releases its bound iron. Iron-free 24p3 can withdraw iron from inside the cell to the outside
by a reverse mechanism. We analyzed the role of the murine 24p3 gene Lcn2 (alias 24p3)
as a target of the Wnt pathway. In cells with activated Wnt pathway, the levels of 24p3 protein …