Biglycan, a nitric oxide-regulated gene, affects adhesion, growth, and survival of mesangial cells
L Schaefer, KF Beck, I Raslik, S Walpen… - Journal of biological …, 2003 - ASBMB
During glomerular inflammation mesangial cells are the major source and target of nitric
oxide that pro-foundly influences proliferation, adhesion, and death of mesangial cells. The
effect of nitric oxide on the mRNA expression pattern of cultured rat mesangial cells was
therefore investigated by RNA-arbitrarily-primed polymerase chain reaction. Employing this
approach, biglycan expression turned out to be down-regulated time-and dose-dependently
either by interleukin-1β-stimulated endogenous nitric oxide production or by direct …
oxide that pro-foundly influences proliferation, adhesion, and death of mesangial cells. The
effect of nitric oxide on the mRNA expression pattern of cultured rat mesangial cells was
therefore investigated by RNA-arbitrarily-primed polymerase chain reaction. Employing this
approach, biglycan expression turned out to be down-regulated time-and dose-dependently
either by interleukin-1β-stimulated endogenous nitric oxide production or by direct …
