[HTML][HTML] Fusion peptides derived from the HIV type 1 glycoprotein 41 associate within phospholipid membranes and inhibit cell-cell fusion: structure-function study
The fusion domain of human immunodeficiency virus (HIV-1) envelope glycoprotein (gp120-
gp41) is a conserved hydrophobic region located at the N terminus of the transmembrane
glycoprotein (gp41). A V2E mutant has been shown to dominantly interfere with wild-type
envelope-mediated syncytium formation and virus infectivity. To understand this
phenomenon, a 33-residue peptide (wild type, WT) identical to the N-terminal segment of
gp41 and its V2E mutant were synthesized, fluorescently labeled, and characterized. Both …
gp41) is a conserved hydrophobic region located at the N terminus of the transmembrane
glycoprotein (gp41). A V2E mutant has been shown to dominantly interfere with wild-type
envelope-mediated syncytium formation and virus infectivity. To understand this
phenomenon, a 33-residue peptide (wild type, WT) identical to the N-terminal segment of
gp41 and its V2E mutant were synthesized, fluorescently labeled, and characterized. Both …
