Not all myofibroblasts are alike: revisiting the role of PDGF-A and PDGF-B using PDGF-targeted mice
P Lindahl - Current opinion in nephrology and hypertension, 1998 - journals.lww.com
P Lindahl
Current opinion in nephrology and hypertension, 1998•journals.lww.comAnalyses of platelet-derived growth factor (PDGF) and PDGF-receptor knockout mice show
that the development of specific subsets of smooth muscle cells (SMCs) depend on PDGF.
Pericytes and mesangial cells failed to develop in PDGF-B deficient emtryos, whereas
alveolar SMCs failed to develop in PDGP-A deficient embryos. The ontogeny of pericytes
and alveolar SMCs suggests a common theme in the formation of PDGF-dependent SMCs,
in which PDGF-receptor positive SMC progenitors spread from proximal to distal sites along …
that the development of specific subsets of smooth muscle cells (SMCs) depend on PDGF.
Pericytes and mesangial cells failed to develop in PDGF-B deficient emtryos, whereas
alveolar SMCs failed to develop in PDGP-A deficient embryos. The ontogeny of pericytes
and alveolar SMCs suggests a common theme in the formation of PDGF-dependent SMCs,
in which PDGF-receptor positive SMC progenitors spread from proximal to distal sites along …
Abstract
Analyses of platelet-derived growth factor (PDGF) and PDGF-receptor knockout mice show that the development of specific subsets of smooth muscle cells (SMCs) depend on PDGF. Pericytes and mesangial cells failed to develop in PDGF-B deficient emtryos, whereas alveolar SMCs failed to develop in PDGP-A deficient embryos. The ontogeny of pericytes and alveolar SMCs suggests a common theme in the formation of PDGF-dependent SMCs, in which PDGF-receptor positive SMC progenitors spread from proximal to distal sites along PDGF-expressing epithelial, or endothelial, tubes.
Lippincott Williams & Wilkins