Publisher Summary Although delta virus requires HBV proteins for its assembly, it is fully
capable of replicating its genome in the absence of helper virus functions. A rolling-circle
mechanism for HDV replication has been proposed, in which a host-encoded RNA-directed
polymerase proceeds multiple times around the circular genome to generate a
complementary multimeric intermediate; cis-Acting catalytic regions on this RNA (ribozymes)
promote site-specific cleavage and ligation to generate a circular unit-length complement of …